What it means
FIFO requires that when you close part of a multi-entry position, the broker closes the lots in the order they were opened. Multiple lots in the same direction are treated as one ordered queue. NFA-regulated US FX brokers must enforce FIFO; most non-US brokers don't.
Why it matters
FIFO breaks any strategy that depends on hedging or on independently managing entry lots. You can't, for example, hold a long EUR/USD entry from yesterday at 1.0800 and open a separate short EUR/USD scalp at 1.0850 — under FIFO the short would automatically close the older long first. Strategies built around independent lot management require a non-US broker.
How to use it
If trading with a US broker, structure your strategy to never have offsetting positions in the same pair simultaneously. For multi-position strategies (hedging, lot-level scaling), use a non-US-NFA broker (IB Pro, Saxo, OANDA-Asia, etc.).
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